Catalog No: FT-0630666
Product Name: Flecainide
CAS No.: 54143-55-4
Molecular Formula: C17H20F6N2O3
Molecular Weight: 414.34 g/mol
Flecainide is a potent Class Ic antiarrhythmic agent widely recognized for its strong sodium channel-blocking activity and its pivotal role in both clinical cardiology and experimental electrophysiology. Since its introduction in antiarrhythmic pharmacotherapy in the 1980s, Flecainide has become a benchmark compound for studying cardiac conduction modulation, ion channel pharmacology, and arrhythmogenesis mechanisms.
Also commonly searched under the names Flecainide Acetate, Tambocor®, Flecainide API, and Class Ic Sodium Channel Blocker, this compound has attracted broad attention in cardiovascular drug discovery, translational electrophysiology, and ion channel research.
At Finetech Industry Limited, high-purity Flecainide is supplied for scientific research applications, supporting investigations into sodium channel kinetics, cardiac rhythm regulation, and precision antiarrhythmic therapy development.
Flecainide is structurally classified as a fluorinated benzamide derivative, characterized by high lipophilicity and strong affinity for activated sodium channels. It exerts its pharmacological action by selectively inhibiting the fast inward sodium current (INa), thereby slowing phase 0 depolarization and reducing myocardial conduction velocity. This mechanism stabilizes cardiac excitability and suppresses abnormal impulse propagation.
Unlike Class Ia antiarrhythmics, Flecainide produces minimal effects on repolarization but markedly depresses conduction through:
These electrophysiological properties make Flecainide an essential tool for mechanistic cardiac studies.
Flecainide is extensively used in electrophysiological models to investigate:
Its use in isolated cardiomyocyte systems and Langendorff-perfused heart models provides critical insight into impulse conduction abnormalities.
Atrial fibrillation (AF) remains one of the most prevalent arrhythmias worldwide. Flecainide serves as a valuable pharmacological tool for studying AF initiation, maintenance, and termination.
Experimental studies demonstrate that Flecainide reduces atrial excitability and interrupts reentrant circuits responsible for sustaining AF.
Keywords frequently associated with this field include:
The cardiac sodium channel Nav1.5, encoded by SCN5A, is central to impulse conduction. Flecainide is frequently used as a pharmacological probe to evaluate:
This makes Flecainide highly relevant in precision medicine and channelopathy research.
Recent studies have identified additional activity of Flecainide on intracellular calcium handling, particularly through modulation of ryanodine receptor-associated calcium release.
This has expanded its utility in CPVT research and calcium-triggered arrhythmia models.
Flecainide remains a frontline rhythm-control drug for:
Modern translational research increasingly focuses on individualized antiarrhythmic strategies, where Flecainide serves as a model molecule for therapeutic optimization.
Finetech Industry Limited provides research-grade Flecainide with:
Suitable for:
To facilitate broader scientific search visibility, Flecainide is commonly referenced under:
These terms are frequently used in literature retrieval, procurement searches, and scientific indexing.